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Purpose: To synthesise and evaluate the anti-tumour properties of doxorubicin-loaded xanthan gumfunctionalised cobalt ferrite nanoparticles (CoFe 2 O 4 .NPs@XG-Doxo) under an AC-magnetic field. Methods: Multidimensional magnetic cobalt ferrite (CoFe 2 O 4 ) nanoparticles (NPs) were synthesised by a co-precipitation method. The synthesised cobalt ferrite nanoparticles (CFNPs) were functionalised with xanthine gum (XG) and subsequently characterised by Fourier transform-infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA) and contact angle studies. Vibrating sample magnetometry (VSM) was used for magnetic measurements of the native and XG-coated CFNPs. The microstructural morphology of the uncoated and XG-coated CFNPs was established using scanning electron microscopy (SEM), atomic force microscopy (AFM) and dynamic light scattering (DLS) studies. Finally, the doxorubicin release profile of the drug-loaded functionalised CFNPs was evaluated using an oscillating magnetic field (OMF) apparatus in the presence of an externally applied magnetic field. Results: XG coating decreased the contact angle of the native CFNPs from 92° to 40°, which indicates that it modified the CFNP surface from hydrophobic to hydrophilic. VSM analysis demonstrated that CoFe 2 O 4 .NPs@XG also retained the magnetic characteristics of the bare cobalt ferrite nanocrystals, endorsing its application as a promising magnetic nanovector (MNV). The synthesised CoFe 2 O 4 .NPs@XG-Doxo exhibited significantly higher controlled discharge of doxorubicin at acidic pH (5.0) than at neutral pH (7.4). In vitro analysis revealed the remarkable lower systematic toxicity of XGcoated CoFe 2 O 4 .NPs compared with uncoated CFNPs against Chinese hamster ovary (CHO) and Huh7 cell lines. Conclusion: These results indicate that XG-coated CFNPs are a biocompatible MNV for doxorubicin. Keywords: Cobalt ferrite, Cytotoxicity, Drug delivery, Nanoparticles, Xanthan gum

tropical journal of pharmaceutical research

Synthesis and characterisation of doxorubicin-loaded functionalised cobalt ferrite nanoparticles and their &lt;i&gt;in vitro&lt;/i&gt; anti-tumour activity under an AC-magnetic field