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Purpose: To investigate the effect of the topical decoction of Polygala tenuifolia Willd. and Polygala sibirica L. on a guinea pig model of sore and ulcer. Method: A guinea pig model of sore and ulcer was produced by Staphylococcus aureus , and 80 guinea pigs were evenly divided into eight groups, consisting of five males and five females in each group. Another 10 (5 male and 5 female) guinea pigs were used as the control group. The corresponding liquid medicine was applied to the ulcer site of the animals in each group, and administered the medicine for 6h daily with a continuous applicator for 12 d. Lysozyme content in serum was measured to determine its effects on body tissue morphology. Results: Compared with the control group, the sore skin score of guinea pigs in each dose group of decoction of Polygala tenuifolia Willd. and Polygala sibirica L. was significantly decreased. The skin showed apparent positive pathological changes and serum lysozyme concentration increased significantly (p < 0.05). Conclusion: Decoctions of the two Polygala tenuifolia species exert a good therapeutic effect on the guinea pig model of sore and ulcer for topical use. Keywords: Polygala species, Topical application, Guinea pig, Skin diseases, Lysozyme, Decoction

Effect of topical application of two <i>Polygala tenuifolia</i> species decoction on guinea pig skin