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Purpose: To investigate the antinociceptive effect of the essential oil from the aerial parts of Gundelia. tournefortii (EOGT) in various experimental models Methods: The essential oil from the aerial parts of Gundelia tournefortii was extracted using steam distillation method median lethal dose (LD 50 ) of EOGT was evaluated using the method of Lorke. Antinociceptive effect of EOGT in rats was carried out using chemical (formalin and acetic acid) and thermal (hot-plate) nociceptive tests at doses of 10, 31.6, 100, 316 and 1000 mg/kg. The possible mechanism of action of EOGT was also examined. Results: In acute toxicity test, LD 50 for EOGT was 2500 mg/kg. EOGT at test doses (10, 31.6, 100, 316 and 1000 mg/kg, orally) significantly reduced pain response in all tests in a dose-dependent manner (p < 0.05). Glibenclamide (potassium channel sensitive to ATP antagonist) and yoimbina (α2 adrenergic receptor antagonist), partially antagonized the antinociceptive activity induced by EOGT. However, naloxone (opioid antagonist) and L-NAME (an inhibitor of nitric oxide synthase) did not reverse the antinociception produced by EOGT. Conclusion: Essential oil from the aerial parts of G. tournefortii shows significant antinociceptive activity, which appeared to involve the participation of K+ channels sensitive to ATP and adrenergic receptors. These findings justify in part the traditional use of the plant in the treatment of various painful conditions. Keywords: Antinociceptive, Opioid receptors, Adrenergic receptor, Essential oil, Gundelia tournefortii , Formalin test

tropical journal of pharmaceutical research

Chemical composition and antinociceptive effects of essential oil from aerial parts of &lt;i&gt;Gundelia tournefortii&lt;/i&gt; L Asteraceae (Compositae) in rats