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Purpose: To evaluate the effect of the essential oil of Origanum vulgare Linnaeus (Lamiaceae) on the growth of Sporothrix schenckii and Sporothrix brasiliensis. Methods: The chemical composition of the essential oil was investigated by gas chromatography/flame ionization detector (GC-FID). The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined by broth micro-dilution method. Scanning electron microscopy (SEM) was also performed to reveal morphological alterations in Sporothrix spp. cells. Results: The major components of the essential oil were γ-terpinene (30.5 %), carvacrol (15.7 %) and 4-terpineol (13.0 %). γ-Terpinene showed potential antifungal activity with MIC ranging from 62.5 to 500.0 µg mL -1 for S. schenckii, and 125.0 to 250.0 µg mL -1 for S. brasiliensis. SEM micrographs revealed morphological alterations in hyphae and reduction of the adhered conidia numbers. Conclusion: Origanum vulgare Linnaeus essential oil possesses potential antifungal activity, and can, therefore, can be developed as an alternative agent for the treatment of sporotrichosis.

tropical journal of pharmaceutical research

Chemical Composition and Antifungal Properties of Essential Oil of &lt;i&gt;Origanum vulgare&lt;/i&gt; Linnaeus (Lamiaceae) against &lt;i&gt;Sporothrix schenckii&lt;/i&gt; and &lt;i&gt;Sporothrix brasiliensis&lt;/i&gt;