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Purpose : To determine and compare the antioxidant, antiproliferative and apoptotic effects of leaf infusions of Ilex laurina and Ilex paraguariensis in colon cancer cells. Methods : Antioxidant activity was determined by ORAC (Oxygen Radical Absorbance Capacity) and FRAP (Ferric Reducing Antioxidant Power). Cytotoxic and antiproliferative effects were analyzed using MTT ((3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) and sulfhorodamine-B respectively. Cell death and apoptosis of human colon adenocarcinoma cells SW480 and their metastatic-derived SW620 cells, were analyzed by flow cytometry using propidium iodide and Annexin-V. Results : Although their flavonoid levels were similar, I. laurina infusion contained 2.2 and 4.4 times higher amounts of total phenolic and caffeoyl derivatives, respectively, than I. paraguariensis . FRAP and ORAC values for I. laurina infusion were 1.6 and 2.0 more active than I. paraguariensis . Both plant infusions inhibited viability and cell growth of SW480 and SW620 cells. These results may be associated to cell cycle-arrest and apoptosis because of the comparable increase of hypodiploid and annexin-V positive colon cancer cells. Conclusion : These data highlight the antioxidant and promising anticancer activities of I. laurina and Ilex paraguariensis. Keywords : Ilex laurina, Ilex paraguariensis , Antioxidant, Antiproliferative, Apoptosis, Colon cancer

tropical journal of pharmaceutical research

Comparative Antioxidant, Antiproliferative and Apoptotic Effects of &lt;i&gt;Ilex laurina&lt;/i&gt; and &lt;i&gt;Ilex paraguariensis&lt;/i&gt; on Colon Cancer Cells