English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Purpose : To investigate the antioxidant activity and hepatoprotective effect of deinoxanthin-rich extract from Deinococcus radiodurans (EDR) against CCl4-induced liver injury in mice. Methods : The ethanol extract of EDR was analyzed by liquid  chromatography/mass spectrometry (LC/MS), and its antioxidant activity was examined using in vitro assays for reducing power, iron chelating activity and lipid peroxidation. The extract was also evaluated for its hepatoprotective activity against carbon tetrachloride-induced liver injury in mice. The activities of alanine aminotransferase (ALT), aspartate  aminotransferase (AST), alkaline phosphatase (ALP) in serum, and catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in liver tissue, as well as hepatic malondialdehyde (MDA) levels, were measured to monitor liver injury. Damage to liver cells was assessed by histology. Results : EDR displayed strong reducing activity and lipid peroxidation inhibition activity in vitro. Pretreatment with EDR (400 mg/kg b.w.)  significantly reduced activities of serum ALT, AST and ALP, as well as hepatic MDA levels (p < 0.05), but increased the activities of GSH-Px, CAT and SOD. Histopathological assessment showed that liver tissue damage was decreased by the protective effect of EDR. Conclusion : The results show that EDR can protect mice against  CCl4-induced hepatic damage by its antioxidant and free radical  scavenging activities. Keywords : Antioxidant, Deinoxanthin, Deinococcus radiodurans,   Hepatoprotective, Carbon tetrachloride, Liver damage

tropical journal of pharmaceutical research

Antioxidative and Hepatoprotective Activities of Deinoxanthin-Rich Extract from &lt;i&gt;Deinococcus radiodurans&lt;/i&gt; R1 against Carbon Tetrachloride-Induced Liver Injury in Mice