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Purpose: To investigate the antiglycation and cross-link breaking activities of Sri Lankan low-grown orthodox Orange Pekoe grade black tea (Camellia sinensis L) Methods: Five concentrations (6.25, 12.5, 25.0, 50.0 or 100.0 µg/ml) of Black tea brew (BTB) were made using Sri Lankan low-grown Orange Pekoe (O.P.) grade tea. Antiglycation and advanced glycation end products (AGEs) cross-link breaking activities of BTB as well as the antiglycation activity of rutin were determined in vitro on bovine serum albumin/glucose system using fluorescence spectroscopy. Results: BTB induced significant (p<0.05) antiglycation activity (IC50, 19.04 ± 5.18 µg/ml) and AGEs cross-link breaking activities (IC50, 82.89 ± 3.44 µg/ml). These effects were dose-dependent. Further, the antiglycation activity of BTB was comparable to rutin, a well-known antiglycation agent (IC50, 21.88 ± 2.82 µg/ml). Conclusion: These results show that Sri Lankan low-grown O.P. grade black tea possesses both antiglycation and AGEs cross-link breaking activities in vitro and thus provides scientific justification for the use of black tea in Sri Lankan indigenous medicine for the management of diabetic complications.

tropical journal of pharmaceutical research

&lt;i&gt;In vitro&lt;/i&gt; Antiglycation and Cross-Link Breaking Activities of Sri Lankan Low-Grown Orthodox Orange Pekoe Grade Black Tea (&lt;i&gt;Camellia sinensis&lt;/i&gt; L)