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Purpose: To provide an online and non-contact method to monitor the dynamic temperature of the nuxvomica parching in sands, and also to develop a rapid screening and comparison of the compounds in crude and processed nux-vomica. Methods: Seeds of nux-vomica were parched in sands by an herbal medicine roaster with an onlinetype and non-contact temperature measurement system (ONTMS). Processing was monitored by ONTMS and the processing temperature was accurately controlled within the range 200 - 220 o C. Ultra performance liquid chromatography - linear trap quadrupole -orbitrap-mass spectrometry method in positive ionization mode was established in this work. The samples were extracted by ultrasonication with 50 % methanol for 30 min. Chromatographic separation was achieved on an Acquity UPLC HSS T3 column using a gradient program with acetonitrile and 1 % formic acid as the mobile phase and a diode array detector set at 254 nm for quantification. Results: The surface color of the processed seeds of nux-vomica were brown or dark brown and the cross-section bulged with small bubble which meets the requirements of Chinese traditional processing methods. Fourteen major compounds from crude and processed nux-vomica were identified simultaneously by HPLC-DAD. According to the MS fragmentation pathways and by comparing with reference literature, the structures of eleven of the compounds were confirmed. Conclusion: Methods using ONTMS are more accurate for parching nux-vomica in sands and UPLCLTQ-Orbitrap-MS is a rapid and straightforward method for compound profiling in crude and processed nux-vomica.

tropical journal of pharmaceutical research

Online monitoring for &lt;i&gt;Strychnos nux-vomica&lt;/i&gt; parching in sands and chemical compositional analysis by ultra performance liquid chromatography - linear trap quadrupole -orbitrap- mass spectrometry