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Purpose: Bidens pilosa , Cleistopholis paterns , and Tetrapleuratetraptera are plants that are used traditionally for cancertreatment, as well as anti-bacterial, and anti-inflammatory agents inAfrica. We used the Ames test to evaluate the bacterial reversemutation effects in these plants. Methods: In the in vitro Ames test,Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 andEscherichia coli WP2uvrA were used with or without metabolicactivation by S9 mix. The highest concentration of B. pilosa, C.paterns, and T. tetraptera for the Ames test was established at 5000µg/plate. Results: B. pilosa, C. paterns, and T. tetraptera didnot cause any increase in the number of his+ revertant coloniescompared to the negative control values obtained from S. typhimuriumand S. typhimurium WP2uvrA strains, with or without the addition of S9mixtures. The results indicated that these plants are non-mutagenic toall the five S. typhimurium and S. typhimurium test strains in thepresence and absence of metabolic activation. Conclusion: B. pilosa,C. paterns, and T. tetraptera showed negative results in the bacterialreverse mutation test, suggesting that it is potentially safe to usethem as medicinal plant supplements even at high doses.

tropical journal of pharmaceutical research

Absence of Mutagenicity in Three Nigerian Medicinal Plants - &lt;i&gt;Bidens pilosa&lt;/i&gt;, &lt;i&gt;Cleistopholis paterns&lt;/i&gt; and &lt;i&gt;Tetrapleura tetraptera&lt;/i&gt;