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Background : Heat injury with consequent coagulation necrosis of skin layers provides an environment that is suitable for bacterial infection as a result of low tissue perfusion and high protein content. Gram negative bacteria and especially Pseudomonas aeroginosa have been recognized as the main causative organisms of burns wound infection. For long time, mankind has been interested in remedial role honey. The role of honey in deep burns wound remains especially after massive secondary bacteria infection has not been sufficiently if documented. Materials and method : In this study, 60 Indian piggies were categorised into three equal groups. A part of the skin of each piggy approximately 8.5cm 2 , was burned with steam (third degree burns). The wounds were each subsequently inoculated with 10 8 Pseudomonas aeroginosa. For each group a specific dressing agent was used to cover the wounds (honey, 1% silver sulfadiazine or 8.5%Acetatmafenid).On specific days, according to a formulated schedule, the weight of the animals, the condition and extent of wounds were recorded. Culture specimens were also taken for qualitative and quantitative analysis periodically. Results : Out of the three groups the Honey group had the least contamination in prepared specimens on the tenth day (20% compared with 95% and 100% in the other groups), the smallest remaining wound (percentage dwindle in size) 62%, compared to 29% and 22% in the other groups) and the most formation of granulation tissue (90% compared with 35% and 44% in the other groups) at 10 days. Mortality was also least in the honey group (30% with 40% and 45% in the other two groups). Conclusion :The topical use of honey in deep burn wounds contaminated with pseudomonas aeroginosa is superior to silver sulfadiazine and Acetatmefamid in terms of granulation tissue formation, wound healing and antimicrobial effect. Keywords : Indian piggy, honey acetatmafenid, silver sulfadiazine Nigerian Journal of Surgical Research Vol. 7(3&4) 2005: 293-295

Utilisation of topical honey in burns wounds contaminated with pseudomonas aeroginosa compared with silversulfadiazine and acetatmafenid