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The comparative effects of chronic [28 days] consumption of kola nut and its active constituent, caffeine diets on locomotor behaviour and body weights in mice were investigated. Thirty adult Swiss white mice [15-30 g body weight], were used for the study. The open field-maze was employed for the evaluation of locomotor behaviour. Mice in the control group [n=10] were fed normal rodent chow, mice in the kola nut-fed group [n=10] were fed kola diet [25 % wt/wt of rodent chow] while those in the caffeine-fed group [n=10] were fed caffeine diet [0.66% wt/wt of rodent chow] for 4 weeks. All animals were allowed free access to clean drinking water. Daily food intake, water intake and body weight change were also measured. Daily food intake in the kola nut and caffeine-fed group of mice was significantly [P&lt;0.001 respectively] lower than the control. There was also a significant [P&lt;0.001] decrease in daily water intake in the caffeine-fed group compared to the control whereas, the apparent decrease of water intake in the kola nut-fed group was not significantly different from the control. Body weight change was also significantly [P&lt;0.001 and P&lt;0.05 respectively] lower in the kola nut and caffeine-fed groups of mice when compared to the control. The frequency of rearing in the open field was significantly [P&lt;0.01] lower in the caffeine-fed group of mice when compared to the control. The frequency of grooming was also significantly [P&lt;0.05] lower in the caffeine-fed group of mice when compared to the control. There was also a significant [P&lt;0.05] decrease in the frequency of light-dark transitions in the light/dark transition box for the caffeine-fed group when compared to the control. The results showed that chronic consumption of kola nut and caffeine diets caused decrease in food intake and body weight. Consumption of caffeine-diet also significantly decreased water intake and locomotor activity. The effect of kola nut-diets on water intake and locomotor activity was not significant. Hence, the effect of kola nut on locomotor behaviour and water intake may not be due to caffeine only.

The Comparative Effects Of Chronic Consumption Of Kola Nut (Cola nitida) And Caffeine Diets On Locomotor Behaviour And Body Weights In Mice