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Purpose: Neocarya macrophylla has a wide range of medicinal uses in traditional medicine. The aim of the study was to isolate and characterize compound(s) from the stem bark of the plant. Methods: (-)-Epicatechin (a flavan-3-ol) was isolated from the ethylaceate soluble fraction of the methanol stem bark extract of Neocarya macrophylla using a combination of silica gel and sephadex LH-20 column chromatography. Results: The structure of the compound as (-)-epicatechin was confirmed on the basis of chemical test, 1D- & 2D-NMR spectroscopy and comparison with existing data in the literature. Conclusion: This is the first report of isolation of epicatechin from the stem bark of the plant.

Isolation of Epicatechin from the Stem Bark of <i>Neocarya macrophylla</i> (Sabine) Prance (Chrysobalanaceae)