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This work reports the synthesis, characterization of new (2E)-1-(biphenyl-4-yl)-3-aryl)-prop-2-en-1-one derivatives ( C1-C10 ). The chalcone derivatives were evaluated for in vitro antibacterial, antifungal, antioxidant activities. All the compounds exhibited moderate to good antimicrobial activity  at MIC 10-40 µg/mL.  The compounds were  docked at the active site of the methionyl-tRNA synthetase (metRS) (PDB ID: 1A8H) to predict their putative interactions.  The compounds further screened for antioxidant property, amid C5, C7 and C8 exhibited excellent DPPH radical scavenging activity. Compound C5 was selected for antistress studies against gamma radiation induced oxidative stress markers in E .coli K 12.   The C5  pretreatment and irradiated bacteria sample  showed  modulatory action of  stress enzymes SOD and CAT to near basal level and significant demulating  effect on the level of TBARS.

Antistress and antimicrobial studies of biphenyl chalcone derivatives