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With the emergence of multidrug-resistant organisms, combining medicinal plants with synthetic medicines against resistant bacteria becomes necessary. In this study, Synergism between plant extracts (methanolic extract and essential oils of Inula viscosa and Anacyclus valentinus) and two commonly used antibiotics (gentamycin, oxacillin) were investigated on three bacterian strains (E. coli, Bacillus subtilis, Staphylococcus aureus). In the first time, the antibacterial effect of extracts alone was tested against 7 strains by disc diffusion and microdilution methods. The minimum inhibitory concentrations of methanolic extracts ranged between 6.25 and 50mg/ml while that of the essential oils varied between 12.5 and 100µL/mL. Interactions extracts /antibiotics and extracts/extracts by checkboard. The results show that the synergistic effect of combinations plant extracts/antibiotics was more important than extracts/extracts.</p

revue des sciences fondamentales et appliquées

The antibacterial effect of two medicinal plants &lt;i&gt;Inula viscosa&lt;/i&gt;, &lt;i&gt;Anacyclus valentinus&lt;/i&gt; (Asteraceae) and their synergistic interaction with antibiotic drugs