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Salmonella enterica  are among the foodborne pathogens of importance due to their involvement in a number of foodborne outbreaks, illnesses and occasionally death. This study was carried out in the Tamale metropolis of Ghana to investigate the prevalence and antibiotic resistance of  Salmonella enterica  in cow milk, cow milk products and hands of cow milk sellers. The conventional method and the disc diffusion method were used for the isolation and antibiotic resistance of  Salmonella enterica , respectively. The overall prevalence of  Salmonella enterica  was 7.3% (22/300).  Salmonella enterica  were detected in 24.0% (12/50) of raw ‘wagashie’, 8.0% (4/50) of fried ‘wagashie’, 6.0% (3/50) of cow milk, 4.0% (2/50) of left hand swab of milk sellers, and 2.0% (1/50) of right hand swab of milk sellers.  Salmonella enterica  was not isolated from ‘brukina’. The prevalence of  Salmonella enterica  did not differ (P = 0.193) among fried ‘wagashie’, cow milk, hand swab of milk sellers and ‘brukina’ samples. However, the prevalence of  Salmonella enterica  in raw ‘wagashie’ was significantly higher (P = 0.000) than the other samples examined. Resistant to erythromycin (86.0%) was most frequently detected. The  Salmonella enterica  isolates were highly susceptible to ciprofloxacin (100.0%), chloramphenicol (91.0%), ceftriaxone (91.0%), sulphamethoxazole/trimethoprim (91.0%), tetracycline (86.0%) and ampicillin (86.0%). Of the 22  Salmonella enterica  isolates, 14 were resistant to only one antibiotic, 4 were resistant to two antibiotics and 2 were resistant to three antibiotics. Two  Salmonella enterica  isolates were resistant to none of the antibiotics. This study revealed that some milk products and other samples were contaminated with  Salmonella enterica . The isolated  Salmonella enterica  were susceptible to most of the antibiotics examined but were highly resistant to erythromycin.   Keywords:  Antimicrobials, Foodborne pathogens, Food safety, Milk, Milk products

journal of applied science and environmental management

Prevalence and antibiotic susceptibility of &lt;i&gt;Salmonella enterica&lt;/i&gt; isolated from cow milk, milk products and hands of sellers in the Tamale Metropolis of Ghana