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Objectif: Etablir des bases scientifiques de l’action antifongique de E. prostrata (L.) L. (Asteraceae), une plante medicinale frequemment utilisee contre les infections cutanees en medecine traditionnelle et recensee lors d’une enquete ethnobotanique realisee dans le district d’Abidjan (Cote d’Ivoire).Methodologie et Resultats: Apres le tri phytochimique par reactions colorees, l’extrait ethanolique 70 % issu de cette plante a ete teste sur la croissance in vitro de trois champignons par la methode de double dilution en tubes penches sur gelose Sabouraud. Les resultats ont revele la presence de divers metabolites secondaires et ont montre que cet extrait a une activite antifongique dose-dependante. Cependant, il a un meilleur potentiel antifongique sur T. mentagrophytes (CMF= 6,25 mg/ml et CI50 = 0,54 mg/ml) que sur C. neoformans (CMF = 25 mg/ml et CI50 = 0,75 mg/ml) et C. albicans (CI50 = 6,25 mg/ml et CMF>50 mg/ml).Conclusion et application des resultats: Ce travail justifie l’utilisation en milieu traditionnel de cette plante comme antifongique. En outre, cet extrait peut servir a la mise au point d’un phytomedicament contre les dermatophytoses a Trichophyton.Mots cles: Antifongique, dermatophytose, Eclipta prostrata, extrait ethanolique, tri phytochimiqueEnglish AbstractObjective: to establish scientific bases of the antifungal action of E. prostrata (L.) L. (Asteraceae), a medicinal plant frequently used against cutaneous infections in traditional medicine and collected during an ethnobotanical survey carried out in the Abidjan district (Cote d’Ivoire).Methodology and Results: After the phytochemical sorting by color reactions, the 70% ethanolic extract from this plant was tested on the in vitro growth of three fungi by the double dilution method in tubes bent on Sabouraud agar. The results revealed the presence of various secondary metabolites and showed that this extract has a dose-dependent antifungal activity. However, it has a better antifungal potential on T. mentagrophytes (CMF = 6.25 mg/mL and IC50 = 0.54 mg/mL) than on C. neoformans (CMF = 25 mg/mL and IC50 = 0.75 mg/mL) and C. albicans (IC50 = 6.25 mg/mL and CMF > 50 mg/mL).Conclusion and application of the results: This work justifies the use in traditional environment of this plant as anti-fungal. In addition, this extract can be used for the development of a phytomedicine against Trichophyton dermatophytosis.Keywords: Antifungal, dermatophytose, Eclipta prostrata, ethanolic extract, phytochemical sorting

journal of applied biosciences

Étude botanique, tri phytochimique et évaluation de l’activité antifongique de l’extrait éthanolique des feuilles de &lt;i&gt;Eclipta prostrata&lt;/i&gt; (L.) L. (Asteraceae) sur la croissance &lt;i&gt;in vitro&lt;/i&gt; de trois souches fongiques