English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

A preliminary study had shown that C. olitorius has analgesic activity possibly mediated through opioidergic pathway. The study was a follow up work to evaluate the anti-nociceptive effects and other possible mechanisms of action of an aqueous leaf extract of C. olitorius (COE) using formalin-induced nociception test. COE was screened for its analgesic, and antioxidant activities. The anti-nociceptive effect of COE (3x10 -2 , 1x10 -1 and 3x10 -1 g kg -1 , p.o), and morphine (1x10 -3 , 3x10 -3 and 1x10 -2 gkg -1 , i.p.) were evaluated using the formalin-induced nociception test. The study showed that C. olitorius has analgesic activity possibly mediated through opioidergic pathway. COE produced significant (P ˂ 0.05) dose-dependent antinociceptive effects similar to morphine in both phases of formalin-induced nociception. The extract showed free radical scavenging properties and different phyto-constituents such as alkaloids, flavonoids, saponins, cardiac glycosides, tannins, anthraquinones and terpenoids were identified. COE has both central and peripheral anti-nociceptive effects mediated through opioidergic receptor activation and also partly through ATP-sensitive K + channel activation systems. The findings confirms earlier reports, and further shows that C. olitorius produces anti-nociception by interrupting many pain processing pathways. Results further suggest that the extract (COE) might possess some chemical constituents that are responsible for the analgesic and the antioxidant activities. Keywords : Naloxone, glibenclamide, morphine, nociception, DPPH, formalin test.

Anti-nociceptive and antioxidant activities of an aqueous leaf extract of <i>Corchorus olitorius </i>L. (Tiliaceae)