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Enteric fever has been associated with adverse multiple-organs perturbation with the liver proposed to be most remarkably affected. In this study, the influence of enteric fever on transaminases [aspartate transaminase (AST), and alanine transaminase (ALT)] was studied using a total of 116 subjects comprising of 55 enteric fever patients (age=27.19 ± 8.05 years) and 61 (age=26.3 ± 7.44 years) apparently healthy control individuals. The enzyme activities were measured spectrophotometrically by Reitman-Frankel Methodology. The result showed that the level of aspartate transaminases in the typhoid patients was 41.56 ± 18.67 U/l, and significantly higher (P females (7.49 ± 3.66 U/l). We opine that transaminases might be accessible markers of hepatic involvement in enteric fever, its estimation should be widely adopted in the diagnostic and prognostic management of affected patients.

Pattern of serum transaminases in enteric fever patients attending Ebonyi State University Teaching Hospital, Abakaliki