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This study investigated the effects of oral administration of Croton penduliflorus seed oil (CSPO) and Depo provera on liver and kidney function of pregnant rabbits. Graded doses of CSPO were suspended in 5% Tween 20 solution. Twenty-five pregnant Dutch-white rabbits at mid–gestation were allocated into 5 groups. Group 1 animals served as control and received 1ml daily of 5% Tween 20 while groups 2-4 received 50, 100 or 150 mg/kg body weight oral dose of CPSO for 10 consecutive days. Animals in group 5 received one intramuscular injection of 2.73 mg/kg of Depo provera. Withdrawal of treatment was followed by 18 hrs fast, and then sacrificed. Blood samples from fasted animals were collected from all groups and analyzed for liver and kidney function parameters. CSPO caused significant (P © 2010 International Formulae Group. All rights reserved. Keywords: Croton penduliflorus , Depo provera, biliary obstruction.

international journal of biological and chemical sciences

The effects of oral administration of &lt;i&gt;Croton penduliflorus&lt;/i&gt; seed oil and Depo provera on liver and kidney functions of pregnant Dutch-white rabbits