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To assess the seriousness of the global counterfeiting problem, we quantified the amount of active ingredient present in paracetamol tablets by various official and non-official methods. Eight brands of Paracetamol 500mg tablets were assessed using the quality control parameters of weight uniformity, active ingredient content, thin layer chromatography profile, disintegration tests and visual inspection. The results were subjected to statistical analysis using GraphPad PRISM. One-way analysis of variance (ANOVA) was used to examine differences between the different brands of paracetamol with Dunnett Multiple Comparisons post test analysis. In all cases, P value of © 2010 International Formulae Group. All rights reserved. Keywords: Drug quality control, counterfeit medicines, paracetamol tablets, analgesic.

An assessment of the quality of various brands of paracetamol tablets sold in the Nigerian capital city