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The effect of oral administration of thiocyanate, t ellurite and hydroxyurea on haematological profile in albino rats was investigated in this study. Rats wer e divided into four groups. Control group received d istilled water while the three experimental groups were administered with each of the antisickling drug daily a t their therapeutic dose for a period of 28 days. All the d rugs significantly increased packed cell volume (PC V), haemoglobin concentration (Hb) and mean corpuscular volume (MCV) in the blood of the rats in vivo . Hydroxyurea and thiocyanate caused significant redu ction in red cell distribution width (RDW), platelet s count and reticulocytes. Tellurite significantly reduced (P <0.05) red blood cell count (RBC) and mean corpuscular haemoglobin concentration (MCHC) while platelets and reticulocytes were significantly elevated by the d rug. In addition, hydroxyurea significantly reduced whit e blood cell count (WBC) in the rat’s blood while thiocyanate caused a reduction in blood pH. These r esults revealed some information on the positive an d negative effects of the drugs on blood parameters w hich is useful in considering their suitability for the treatment of sickle cell disease. © 2009 International Formulae Group. All rights res erved.

Haematological evaluation in rats following administration of some antisickling agents