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Zizyphus spina-christi (ZS) Willd is reputed to have medicinal values. Studies on the phytochemistry, and some pharmacological activity of the plant\'s rootbark were initiated in our laboratories. The present study is a report on sedative effect of a fraction obtained from the hexane extract (numbered ZS-1A) of the plant material. The fraction (25, 50 and 100 mg/kg, p.o.) were tested against pentobarbital sleeping time, motor coordination (rota-rod performance) test and exploratory behaviour in mice. Results show that ZS-1A prolonged pentobarbital induced hypnosis and decrease the head-dip responses in the exploratory behaviour tests dose dependently. It however failed to give a positive test on the motor coordination test. The results demonstrate potent central depressant effect by ZS-1A. Keywords : Phytomedicine, sedation, mice. International Journal of Biological and Chemical Sciences Vol. 2 (4) 2008: pp. 456-461

CNS activity of ZS-1A: a phytoceutical from <i>Zizyphus spina-christi</i> root bark