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L’objectif de cette etude etait, de comparer six methodes de dosage indirect du cholesterol LDL en vue de mettre en place une methode plus pertinente dans le suivi des modifications cardiometaboliques chez les personnes vivant avec le VIH (PVVIH) sous traitements. Il s’agissait d’une etude prospective descriptive et analytique chez des PVVIH sous antiretroviraux a Libreville, allant du 13 aout au 30 novembre 2018. Les patients de plus de 15 ans ont ete inclus apres avoir donne leurs consentements. Le dosage du cholesterol total, cholesterol HDL, cholesterol LDL et triglycerides a requis un automate multi analyseur (BS 200 de Mindray®) ainsi que des kits « BIOLABO ». La regression lineaire etait utilisee pour rechercher les differentes correlations. Les valeurs de triglycerides <150mg/dL etaient retrouvees chez 96% de la population et 52% avait une concentration de cholesterol HDL <40mg/dL. Les differentes formules de calcul de la concentration du cholesterol LDL par rapport aux  concentrations de LDL cholesterol direct ont montre que le carre du coefficient de correlation lineaire r etait plus eleve pour la formule  d’Anandaraja (r2 = 0,83), suivi de celle de Friedewald avec r2 = 0,72. Un palliatif au dosage direct pourrait etre l’utilisation de la formule d’Anandaraja dans notre contexte d’etude.Mots cles : Cholesterol LDL, Cholesterol total, Methode indirecte, VIH, Anandaraja, Friedewald. Comparison of six indirect LDL cholesterol methods among HIV patients in Libreville   The objective of this study was to compare six methods of indirect measurement of LDL cholesterol for setting a more relevant method of monitoring cardiometabolic changes in people living with HIV under treatment. This was a prospective descriptive and analytic study among people living with HIV and under antiretroviral therapy in Libreville, from 13 August to 30 November 2018. Patients over 15 years of age were included after giving their consent. The dosage total of cholesterol, HDL cholesterol, LDL cholesterol and triglycerides required a multi analyzer BS 200 of Mindray® and reagents kits from BIOLABO. Linear regression was used to found different correlations. Triglyceride values below 150 mg/dL were found among 96% of the population and 52% had HDL cholesterol concentration below 40 mg/dL. The different formulas for calculating the LDL cholesterol concentration relative to the direct LDL cholesterol concentrations show that the square of the linear correlation coefficient r is higher for the Anandaraja formula (r2 = 0.83) followed by that of Friedewald with r2 = 0.72. A palliative method to the direct assay could be the use of Anandaraja's formula in our context.Keywords: LDL cholesterol, Total cholesterol, Indirect method, HIV, Anandaraja, Friedewald.

Comparaison de six méthodes de dosage indirect du cholestérol LDL chez des personnes vivant avec le VIH à Libreville