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La drepanocytose est caracterisee par une grande variabilite d’expression clinique et biologique qui depend de plusieurs facteurs. L’objectif de ce travail etait d’etudier les perturbations biologiques des patients drepanocytaires homozygotes en phase stationnaire. Il s’agit d’une etude prospective transversale ayant inclus 100 drepanocytaires homozygotes en phase stationnaire d’âge superieur a 15 ans. Chaque patient a beneficie de deux tubes de prelevements pour l’etude des parametres hematologiques et pour les dosages biochimiques. Un questionnaire a ete utilise pour recueillir les variables epidemiologiques, cliniques et biologiques. Ces donnees ont ete saisies et analysees par le logiciel Epi-info 7.2. Une valeur p ≤ 0,05 a ete consideree comme significative. L’âge moyen des patients etait de (28 ± 8,94) ans, les extremes (15-57 ans) et le sex-ratio (H/F) de 0,75. Le taux d’hemoglobine de base etait en moyenne de (8,2 ± 1,4g/dl), les globules blancs de (12352 ± 6.906/ mm 3 ), les plaquettes (439.920 ± 139.000/mm 3 ), la TCMH (31,18pg ± 4,12 pg). Le taux d’hemoglobine S etait en moyenne de (87,79 ± 8,19 %) et l’hemoglobine F (HbF) (9,5 ± 8,3%). Le taux HbF etait associee de facon significative avec le syndrome thoracique aigu et la lithiase biliaire (r=0,56 ; p=0,003). Cette etude a montre que les perturbations biologiques sont frequentes chez les dans la drepanocytaires homozygotes. Leur connaissance servira de base de comparaison lors des crises et pour evaluer l’efficacite du traitement. © 2017 International Formulae Group. All rights reserved. Mots cles: Drepanocytose SS, phase stationnaire, perturbations biochimiques, hematologiques English Title: Biochemical and hematological profile of homozygous sickle cell patients in stationary phase at the Blood Transfusion National Center of Dakar English Abstract Sickle cell disease is frequently associated with a high clinical and biological variability. This study aimed to describe biological abnormalities in Senegalese patients with homozygous sickle cell disease. In a cross-sectional study, we included 100 patients aged 15 years with homozygous sickle cell disease. Hematological and biochemical parameters were assessed for each patient. Clinical, epidemiological and biological variables were collected using a questionnaire. Data were analyzed using Epi-info 7.2. The mean age of patients was (28 ± 8.94) years and sex ratio (H/F) was 0, 75. The basal hemoglobin level was (8.2 ± 1.48 g / dl), white blood cells (12352 ± 6.906/ mm 3 ), platelets (439.920 ± 139.000/ mm 3 ), TCMH (31, 18 ± 4.12 pg). The mean Hemoglobin S was (87.79 ± 8.19%) and hemoglobin F (HbF) (9.5 ± 8.3%). HbF was associated with acute chest syndrome and biliary lithiasis (r=0, 56; p=0,003). This study showed that biological abnormalities in homozygous sickle cell patients in the stationary phase are frequent. The base line characteristics will help for comparison during next crises and for assess effectiveness of treatment. © 2017 International Formulae Group. All rights reserved. Keywords: Sickle cell disease, stationary phase, biochemical disturbances, hematological

Profil biochimique et hématologique des patients drépanocytaires homozygotes en phase stationnaire au centre National de Transfusion Sanguine de Dakar