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Les plantes medicinales sont des veritables sources de molecules bioactives. L’objectif de la presente etude a ete de tester les effets de l’extrait hydroethanolique de Lippia multiflora sur le coeur isole de crapaud et d’elucider son mecanisme d’action probable. Cet extrait a ete obtenu apres extraction aux solvants a polarite croissante. Le coeur de crapaud a ete isole et perfuse avec le ringer normal puis avec les differents produits selon le dispositif de Langerdhorff de mesure de la force et la frequence des contractions du coeur. Les resultats obtenus montrent que l’extrait hydroethanolique de Lippia multiflora provoque des effets inotrope et chronotrope positifs sur le coeur isole de crapaud, semblables a ceux de l’adrenaline bien que moins marques. Cet extrait semble provoquer l’augmentation de l’influx d’ions calcium consecutif a son action directe sur les recepteurs α1- adrenergiques cardiaques comme l’adrenaline. Les effets de cet extrait etant antagonises par le propranolol et le verapamil. Par ailleurs, cet extrait potentialise les effets inotrope et chronotrope positifs de l’adrenaline sur le coeur isole de crapaud. Ces resultats suggerent que l’extrait hydroethanolique de L. multiflora provoque les effets inotrope et chronotrope positifs probablement suivant le meme mecanisme que l’adrenaline. © 2016 International Formulae Group. All rights reserved. Mots cles: Lippia multiflora , inotrope, chronotrope, CaCl 2 , adrenaline, coeur English Title: Effects of hydroethanolic extract of Lippia multiflora Moldenke on the heart isolated from toad English Abstract Medicinal plants are sources of bioactive molecules. The objective of this study was to test the effects of hydroethanolic extract of Lippia multiflora on the isolated toad heart and to elucidate its likely mechanism of action. This extract was obtained after extraction with solvents of increasing polarity. The toad heart was isolated and perfused with the normal ringer then with different products according to the Langerdhorff device for measuring the strength and frequency of heart contractions. The results obtained show that the  hydroethanolic extract of Lippia multiflora produces positive inotropic and chronotropic effects on the isolated heart of toads, similar to those of adrenaline, although less marked. This extract seems to cause an increase in the influx of calcium ions following its direct action on cardiac α1-adrenergic receptors such as adrenaline. The effects of this extract are antagonized by propranolol and verapamil. Moreover, this extract potentiates the positive inotropic and chronotropic effects of adrenaline on the isolated heart of toad. These results suggest that the hydroethanolic extract of L. multiflora causes the positive inotropic and chronotropic effects probably following the same mechanism as adrenaline. © 2016 International Formulae Group. All rights reserved. Keywords: Lippia multiflora , inotropic, chronotropic, CaCl 2 , adrenalin, heart

Effets de l’extrait hydroéthanolique de <i>Lippia multiflora</i> Moldenke sur le coeur isolé de crapaud