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L’evaluation de la fonction renale est indispensable dans la prise en charge des nephropathies. L’objectif de l’etude etait d’apprecier l’apport de la cystatine C dans l’evaluation de la fonction renale. Il s’agissait d’une etude transversale realisee chez 107 sujets des deux sexes, âges de plus de 18 ans, repartis en deux groupes. Un groupe de 30 sujets apparemment sains et un groupe de 77 patients atteints de maladies cardiovasculaires reparti comme suit : 30 patients atteints d’hypertension arterielle, 28 atteints d’accident vasculaire cerebral et 19 atteints d’infarctus du myocarde. Les serums, obtenus apres traitement des prelevements sanguins, ont servi au dosage des differents parametres. Il ressort de l’etude que, pour les stades precoces de l’insuffisance renale (IR), MDRD (Modification of diet in renal disease) sous-estime le debit de filtration glomerulaire (DFG) alors que la formule de Larsson le surestime; il existe une augmentation exponentielle significative plus nette pour la cystatine C (p = 0,0283) que pour la creatinine (p = 0,0534) en passant d’un stade de l’IR a un autre. La cystatinemie C est un meilleur marqueur du DFG que la creatininemie. Cependant, l’estimation du DFG par les formules basees sur la cystatine C ne presente pas d’avantage par rapport aux formules classiques basees sur la creatinine. © 2016 International Formulae Group. All rights reserved. Mots cles: Cystatine C, creatinine, insuffisance renale, debit de filtration glomerulaire, maladies cardiovasculaires English Title: Evaluation of the renal function in patients with cardiovascular disease (CVD): comparison of creatinine and cystatin C English Abstract Assessment of renal function is indispensable in the treatment of kidney diseases. The objective of the study was to assess the contribution of cystatin C in the assessment of renal function. This was a crosssectional study in 107 subjects of both sexes, aged over 18 years, divided into two groups. A group of 30  apparently healthy subjects and a group of 77 patients with cardiovascular disease allocated as follows: 30 patients with high blood pressure, 28 with stroke and 19 with myocardial infarction. Serum obtained after treatment of blood samples, were used for the determination of the different parameters. According to the study: for the early stages of renal failure, MDRD underestimates GFR while the Larsson formula overestimates GFR; there is a sharper significant exponential increase for cystatin C (p=0.0283) than creatinine (p=0.0534) when passing from one stage to another. Serum cystatin C is a better marker of GFR than creatinine. However, estimates of GFR by formulas based on cystatin C shows no advantage over conventional formulations based on creatinine. © 2016 International Formulae Group. All rights reserved. Keywords: cystatin C, creatinine, renal failure, glomerular filtration rate, cardiovascular disease

Evaluation de la fonction rénale chez les patients atteints de maladie cardio vasculaire (MCV) : comparaison entre la créatinine et la cystatine C