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Les combinaisons therapeutiques antipaludiques a base d’artemether-lumefantrine sous forme de poudres lyophilisees, sont des preparations multidoses destinees aux enfants pour le traitement du paludisme. Dans le but d’obtenir une bonne observance therapeutique chez les enfants, ces poudres lyophilisees a reconstituer ont ete mises sur le marche. La stabilite des suspensions obtenues apres reconstitution avec differents types d’eau accessible a toutes les couches sociales dans les zones endemiques de paludisme a ete evaluee. Les caracteres organoleptiques et le pH des suspensions ont ete recherches. Les teneurs en artemether et en lumefantrine ont ete recherches respectivement par chromatographie liquide et par spectrometrie UV. Les produits de degradation de l’artemether et de la lumefantrine ont aussi ete recherches par chromatographie sur couche mince de gel de silice. Des etudes microbiologiques ont ete realisees pour la recherche des germes anaerobies viables totaux et la recherche d’enterobacteries. L’etude a revele que les caracteres organoleptiques et le pH de chaque suspension ont ete acceptables. Les principes actifs n’ont pas ete degrades apres reconstitutions des poudres lyophilisees dans tous les echantillons durant la periode d’etude. Les concentrations obtenues en artemether et en lumefantrine de tous les echantillons analyses, etaient conformes aux normes. Les echantillons n’ont pas ete contamines par des bacteries, des levures et des moisissures au cours de cette periode d’etude. © 2016 International Formulae Group. All rights reserved. Mots cles: Stabilite, artemether, lumefantrine, suspension, spectrophotometrie, chromatographie English Title: Stability of reconstituted suspension of artemether-lumefantrine lyophilized powders against malaria with different types of water English Abstract The artemether-lumefantrine antimalarial therapeutic combinations in the form of lyophilized powders are multidoses preparations intended for the treatment of children against malaria. For obtaining a good therapeutic observance on the children, the lyophilized powders to be reconstituted were launched on the  market. The stability of the suspensions obtained after reconstitution with various types of water accessible to all sectors of society in the endemic zone of malaria was evaluated. The organoleptic characteristics and pH of the suspensions were evaluated. The concentrations of artemether and lumefantrine were respectively sought by liquid chromatography and UV spectrometry. Also the degradation products of artemether and lumefantrine were searched by thin layer chromatography. Microbiological studies were realized for the search of total viable anaerobic germs and anterobacteria. The study revealed that the organoleptic characteristics and pH of every suspension were acceptable. Active substances were not degraded after reconstitutions of lyophilized powders in all the samples during the period of study. The artemether and lumefantrine concentrations obtained were in agreement with the standards. Samples were not contaminated by bacteria, yeasts and molds during this period of study. © 2016 International Formulae Group. All rights reserved. Keywords: Stability, artemether, lumefantrine, , suspension, spectrophotometry, chromatography

Stabilité des suspensions reconstituées de la combinaison thérapeutique antipaludique à base d’artéméther-luméfantrine avec différents types d’eaux