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Antimalarial drug resistance has been a major contributor to the failure of the battle against malaria in many developing countries. The P. falciparum genes, pfcrt and pfmdr-1, have been implicated in chloroquine resistance. The objective of this study was to determine the presence of mutant alleles of these chloroquine resistance genes among isolates of P. falciparum from children presenting with severe malaria in Ghana.

Resistance-mediating polymorphisms of <i>Plasmodium falciparum</i> among isolates from children with severe malaria in Kumasi, Ghana