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Crude aqueous extract of the root bark of Zanthoxylum xanthoxyloides is used in folklore medicine for its anti-inflammatory activity. Although it shares the analgesic and anti-inflammatory property of non-steroidal anti-inflammatory drugs (NSAIDs), its mechanism of action has not been well elucidated.

In vivo inhibition of prostaglandin e2 production by crude aqueous extract of the root bark of zanthoxylumxanthoxyloides