English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Les derives oxygenes de la pyridazine sont connus en therapeutique pour la richesse de leurs potentiels pharmacologiques : antihypertenseur et cardiotonique. Des proprietes antibacteriennes sont egalement mentionnees dans la litterature. De ces considerations, resulte l’idee de synthetiser et d’etudier de nouvelles series d’arylidenpyridazin-3-ones substituees sur le plan toxicologique, et d’explorer leur activite psychotrope. L'etude de l’activite pharmacologique a demontre que ces produits ne sont pas toxiques aux doses therapeutiques et qu'ils sont doues d'effets sedatif, myorelaxant, anxiolytique mais, ne presentent pas d’effet hypnotique, ni cataleptique. Cependant, ces trois produits de synthese potentialisent a des degres differents l'effet hypnotique du diazepam. Synthesis, toxicological study and psychotropic activity of new arylidenpyridazin-3-ones N-substituted. The oxygenated derivatives of pyridazin are known into therapeutic for the richness of their pharmacological potentials: antihypertensive and cardiotonic. Properties antibacteriennes are also mentioned in the literature. From these considerations, results the idea to synthesize and study new series of arylidenpyridazin-3-ones N-substituted on the toxicological level, but also, to explore their possible activity on the central nervous system, in particular the psychotropic activity. The study of the pharmacological activity has shown that these products are not toxic at therapeutic doses and possess sedative, muscle relaxant, anxiolytic effects, but do not present any hypnotic, or catalepsy effect. However, these three products potentiate synthesis to different degrees of the hypnotic effect diazepam.

Synthèse, étude toxicologique et activité psychotrope de nouvelles arylidènpyridazin-3-ones N-substituées