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The hepatoprotective activity of ethanolic leaf extract of Jatropha tanjorensis (ELEJT) against acetaminophen induced hepatotoxicity using Swiss albino rats was ascertained. The animals were grouped into six with five animals each. Hepatoprotection against acetaminophen-induced toxicity was evaluated using standard methods. Effect on genotoxicity using micronucleus test and spermatogenesis was ascertained. ELEJT significantly (p˂0.05) decreased the levels of serum liver enzymes. At 800 mgkg-1, ELEJT significantly (p˂0.05) reduced triacylglycerol and LDL levels but significantly (p˂0.05) increased the level of HDL compared to the toxin control group. Administration of ELEJT resulted in a dose-dependent increase in the total protein level. Sperm head abnormality was observed more at 800 mgkg -1 while at 400 mgkg -1 binucleated cell and micronuclei cells were detected. ELEJT exhibited hepatoprotective activity against Acetaminophen-induced liver damage using Swiss albino rats. This validates the traditional use of Jatropha tanjorensis in management of liver ailments and improvement of spermatogenesis. However, more work is needed to ascertain its mode of action. Keywords: Spermatogenesis, Hepatoprotective, Genotoxicity, Acetaminophen

Hepatoprotective effect of the ethanolic extract of <i>Jatropha tanjorensis</i> on acetaminophen-induced toxicity in rat model