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Coordination compounds of 4-amino-N-pyrimidin-2-ylbenzene sulphonamide (APS) were synthesized. The complexes were formulated as [Co(APS) 2 (H 2 O) 2 ], [Cu(APS) 2 (H 2 O) 2 ], [Ni(APS) 2 (H 2 O) 2 ], [Cd(APS) 2 ](H 2 O) 2 , [Fe(APS) 3 ](H­ 2 O)­ 3 and [Mn(APS) 2 (H 2 O) 2 ] characterized by elemental analysis, conductivity, IR, UV-Vis, magnet moment and 1 H-NMR and mass spectroscopies. In all the complexes the metal ions coordinate through pyrimidinic nitrogen and sulphonamidic nitrogen of the two molecules of APS. The suggested structure for Cd(II) complex of APS is tetrahedral, while that of Cu(II), Mn(II) and Ni(II) APS complexes is octahedral. The inner coordination spheres were occupied by two water molecules in Co(II), Mn(II), Cu(II), Ni(II) APS complexes except Cd(II) with 2 molecules of  water outside the coordination  sphere. Fe(III) coordinates with 3 molecules of APS with 3 molecules of water outside the coordination sphere. The antiparasitic studies using Plasmodium berghei as test organism showed that the Fe(III) complex exhibits higher activity than chloroquine and  ligand. All other complexes have lower antiparasitic activity. KEY WORDS : Sulphonamide, Antimalarial activity, Plasmodium berghei Bull. Chem. Soc. Ethiop. 2011 , 25(3), 371-380.

bulletin of the chemical society of ethiopia

&lt;b&gt;Divalent metal complexes of 4-amino-N-pyrimidin-2-ylbenzene sulphonamide and their antimalarial activities against &lt;i&gt;Plasmodium berghei&lt;/i&gt;&lt;/b&gt;