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Vernonia oil obtained by Soxhlet extraction from the seeds of Vernonia galamensis ssp. nairobensis was reacted with 2-aminopyridine, 2-(aminomethyl)pyridine and 2-(aminoethyl)pyridine using a 1:3 mole ratio of vernonia oil to amine at varied temperatures to give the corresponding vernolamides. The expected vernolamide from the reaction of 2-aminopyridine and the oil was not formed. N-(2-pyridinylmethyl)vernolamide and N-(2-pyridinylethyl)vernolamide exhibited antibacterial activity that was shown to be higher against gram-positive ( Bacillus subtilis ) than gram-negative ( Escherichia coli ) bacteria. The vernolamides did not show any antifungal activity. KEY WORDS: Vernonia galamensis , 2-Aminopyridine, N-(2-pyridinylmethyl)vernolamide, N-(2-pyridinylethyl)vernolamide, Antimicrobial activity Bull. Chem. Soc. Ethiop. 2007 , 21(1), 103-110.

<b>Conversion of <i>Vernonia galamensis</i> oil to pyridinyl-vernolamides and their antimicrobial activities</b>