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The following studies report the inhibitory effect produced by chemical constituents of essential oils of three plants used in traditional medicine as anti-inflammatory and analgesic drugs, in vitro , on soybean lipoxygenase L-1 and cyclooxygenase function of prostaglandin H synthase (PGHS), the two enzymes involved in the production of mediators of inflammation. The essential oils were extracted from plants of three families: O. gratissimum (Labiatae), C. giganteus ( Poaceae), and E. citriodora (Myrtaceae). Their chemical composition was established by GC/MS analyses. Among the three essential oils, one showed evident inhibition of L-1 with IC 50 value of 72 µg/mL for Eucalyptus citriodora. Only one essential oil that of O. gratissimum inhibited the two enzymes, cyclooxygenase function of PGHS and lipoxygenase L-1, with an IC 50 values, respectively, of 125 µg/mL and 144 µg/mL, whereas that of C. giganteus and E. citriodora, two of them had no effect on cyclooxygenase. KEY WORDS: Essential oils, Soybean lipoxygenase (L-1), Cyclooxygenase function of prostaglandine H synthase-1, PGHS, O. gratissimum (Labiatae), C. giganteus ( Poaceae), E. citriodora (Myrtaceae), Enantia chlorantha , Inhibition Bull. Chem. Soc. Ethiop. 2003 , 17(2), 191-197.

bulletin of the chemical society of ethiopia

&lt;b&gt;Anti-inflammatory and analgesic activities: Chemical constituents of essential oils of &lt;i&gt;Ocimum gratissimum&lt;/i&gt;, &lt;i&gt;Eucalyptus citriodora&lt;/i&gt; and &lt;i&gt;Cymbopogon giganteus&lt;/i&gt; inhibited lipoxygenase L-1 and cyclooxygenase of PGHS&lt;/b&gt;