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This study evaluated the hepato-renal toxicological indices following 21 days administration of ethyl acetate leaf extract of Vitex simplicifolia in Wistar rats. Acute toxicity studies with very high concentrations of the crude extract was carried out followed by sub chronic toxicities studies involving administration of 250mg/kg, 500mg/kg and 1000mg/kg body weight of the ethyl acetate extract to the  experimental animals for 21 days. Liver and Kidney toxicological indices were evaluated from the sera as well as e tissues of the experimental animals after the 21 days period of administration. The results of acute toxicity studies indicate that this extract is well tolerated at doses as high as 5000mg/kg body weight. The results of sub-chronic toxicity studies indicate that there was a significant increase in the activities of ALP , while AST activities was significantly lower (p<0.05) compared to the control. There was no significant changes in (P<0.05) ALT and Unconjugated bilirubin levels in the test groups compared to the control. Similarly, the result of kidney toxicological indices showed that the levels of urea, Na + , HCO 3 2- and Cl - were significantly higher in the test animals compared to the control while K + and creatine levels showed no significant change in the extract  administered groups compared to the control (p<0.05). Histopathology examination of the liver and kidneys showed mild hepatic damage at the highest dose (1000mg/kg body weight). Keywords : Vitex simplicifolia, Hepato-renal, Toxicological Studies.

Hepato-renal toxicological studies of ethyl acetate leaf extract of Vitex simplicifolia in wistar rats