English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

The blood glucose lowering effects of the aqueous leaf extracts of Cassia alata, Acalypha torta and Breynia nivosa, and aqueous root extracts of Daniellia oliveri and Nauclea latifolia traditionally employed in Nigeria in the management of diabetes mellitus were compared in alloxan-induced diabetic Wistar rats. The same dose, 100.0 mg/kg body wt. of each extract was used. Alloxan (150.0 mg/kg body wt.), extracts, and the reference drug, glibenclamide (20.0 mg/70kg body wt.) were solubilized in normal saline and administered intraperitoneally. Investigation into the mechanisms of action of the most potent extract was carried out by determining it’s effects on lipid-peroxidation, superoxide dismutase (SOD), catalase and glucokinase. The extracts caused significant (p Acalypha torta (66.5%) > Breynia nivosa (50.4%) > Cassia alata (39.2%) > Daniellia oliveri (31.9%). The most active extract, Nauclea latifolia, was more potent than glibenclamide.  N. latifolia extract decreased malonylaldehyde concentration and superoxide dismutase activity, although these effects were not statistically significant, whereas significant reduction in catalase activity was noted. Alteration of body’s oxidant-antioxidant balance may be enhancing the antidiabetic activity of Nauclea latifolia root. Glucokinase activity was also significantly (p<0.05) elevated.

Blood glucose lowering activity of five Nigerian medicinal plants in alloxan-induced diabetic wistar albino rats