English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

The antimicrobial susceptibility pattern of Staphylococcusaureus in Umuahia was investigated in this study.A total of 113 strains of S. aureus consisting of 30 isolates from clinical specimens obtained from 10 medical Laboratories and 83 isolates from nasal swabs of University students in Umuahia, were tested against 10 antimicrobial agents using the disc agar diffusion method. Resistance to penicillin, ampicillin, cloxacillin and tetracycline was 100% among strains isolated from clinical specimens. The clinical isolates also exhibited high rates of resistance to chloramphenicol (97%) and erythromycin (97%). Seven (23%) of these isolates were sensitive to Gentamicin and 6 (20%) to Streptomycin. Likewise, all the 83(100%) and 82 (98.8%)were resistant to penicillin and cloxacillin, respectively.Isolates from nasal passages appeared to be less resistant to chloramphenicol (54.2%), gentamicin (43.4), streptomycin (31.3%) and tetracycline (51.8%). Ampicillin did not produce any zone of inhibition against 29 (96.7%) isolates from clinical specimens and only slightly inhibited one with zone of inhibition of 8mm. Nineteen of the isolates manifested low to high level of resistance to chloramphenicol with mean zone of inhibition ranging from 15. 8± 0.7 mm to 9.8± 2.0 mm. All the isolates were completely resistant to penicillin and cloxacillin with no zone of inhibition at all. In the case of gentamicin, 5 (16.7%) had intermediate susceptibility (mean zone of inhibition 14±0 mm), 12(40%) had mean inhibition zone of 9.6±2.9 mm and 6(20%) were not inhibited. This study shows that S. aureus strains isolated from clinical specimens and healthy students in Umuahia are highly resistant to common antibiotics. This may not be unconnected with indiscriminate use of antibiotics and calls for more control and rational use of antibiotics to minimize the rate of development of resistance to other antibiotics. Key words : Staphylococcus aureus , antimicrobial resistance, disc agar diffusion, antibiotic susceptibility French Abstract Le profil de sensibilite antimicrobienne de Staphylococcus aureus a Umuahia a ete recherche dans cette etude. Au total, 113 souches de S. aureus compose de 30 souches provenant d'echantillons cliniques obtenus a partir de 10 laboratoires medicaux et 83 souches d’ecouvillons nasaux des etudiants universitaires a Umuahia, ont ete testees contre 10 agents antimicrobiens par la methode de diffusion disque sur gelose. La resistance a la penicilline, l'ampicilline, la cloxacilline et la tetracycline a ete de 100% chez les souches isolees d'echantillons cliniques. Les souches cliniques ont egalement presente des taux eleves de resistance au chloramphenicol (97%) et a l'erythromycine (97%). Sept (23%) de ces souches etaient sensibles a la gentamicine et 6 (20%) a la streptomycine. De meme, tous les 83 (100%) et 82 (98,8%) etaient resistants respectivement a la penicilline et a la cloxacilline. Les souches de voies nasales semblaient etre moins resistantes au chloramphenicol (54,2%), a la gentamicine (43,4), a la streptomycine (31,3%) et a la tetracycline (51,8%). L'ampicilline n'a produit aucune zone d'inhibition contre 29 (96,7%) souches provenant d'echantillons cliniques et seulement legerement inhibees avec une zone d'inhibition de 8mm. Dix-neuf souches ont manifeste un faible niveau eleve de resistance au chloramphenicol avec une zone d'inhibition moyenne allant de 15. 8 ± 0,7 mm a 9.8± 2,0mm. Toutes les souches etaient completement resistantes a la penicilline et a la cloxacilline sans zone d'inhibition. Dans le cas de la gentamicine, 5 (16,7%) souches avaient une sensibilite intermediaire (zone d'inhibition moyenne de 14 ± 0 mm), 12 (40%) souches ont eu une zone d'inhibition moyenne de 9,6 ± 2,9 mm et 6 (20%) souches ne ont pas ete inhibees. Cette etude montre que les souches de S. aureus isolees  a partir d'echantillons cliniques et des etudiants en bonne sante a Umuahia sont tres resistantes aux antibiotiques courants. Cela peut ne pas etre en rapport avec l'utilisation sans discernement des antibiotiques et des appels pour plus de controle et d'utilisation rationnelle des antibiotiques afin de minimiser le taux de developpement d'une resistance a d'autres antibiotiques. Mots cles : Staphylococcus aureus, resistance aux antimicrobiens, disque de diffusion sur gelose, sensibilite aux

In-vitro antimicrobial susceptibility pattern of <i>Staphylococcus aureus</i> isolates in Umuahia, Abia state, Nigeria