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ethno-medicinal therapies ranging form oral, skin, gastro-intestinal to respiratory problems. The effects of this plant on the sensitivity of microorganisms need verification and its potential for cytotoxicity needs to be investigated. Thus, the anti-microbial and brine–shrimp lethality studies on the leaves and stem were carried out. The crude ethanolic extract of the stem and its ethylacetate fraction elicited good antibacterial activity against clinical strains of Bacillus subtilis, Staphylococcus aureus but gave minimal activity against Escherichia coli, Klebsiella pneumoniae and Salmonella typhi but none against the fungal isolate; Candida albicans. The brine-shrimp lethality assay analyzed using the Finney probit method showed that the crude ethanolic extracts of the leaves and stem displayed LD50 values at 192 ppm and 182 ppm respectively. These findings indicate the potential of the plant as panacea for infectious diseases and also reveal a novel potential in the fight against tumors in man. (Afr. J. Biomed. Res. 9: 205 – 211) Keywords: Anti-microbial, extracts, fractions, brine-shrimp lethality, Calotropis procera

In-vitro anti-microbial and brine-shrimp lethality potential of the leaves and stem of Calotropis procera (ait).