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Antilipidemic and smooth muscle inhibition by kolaviron (KV), a biflavanoid-complex  of Garcinia kola-fraction; informed  the investigation of the hypothesis that KV may prevent elevation in blood pressure and dyslipidemia in hypertension. Thirty-two (32) sprague-dawley rats (inbred) weighing 110-130g were randomly separated into four groups of 8 rats each. Control rats (CR)  were given normal rat chow and water ad libitum. Group 2  was given rat chow containing  8% NaCl (high salt diet-HSD); while the remaining experimental groups were concomitantly given HSD + 200 mg/kg bw/day of KV and/or 2.3 mg/kg bw/day of lisinopril (LP) respectively by oral gavage  for 6 weeks. Measurements of blood pressure [(Bp) (mmHg)] were by the cuff-tail artery  blood pressure and the blood pressure transducer via cannulation of the left common carotid artery following anaesthesia with urethane. The heart rate [(HR)(bpm)] was determined by counting the number of arterial pulses over a period of 60 seconds. 5 ml of blood was collected from the carotid artery for lipid profile including total cholesterol (TC), Triglycerides (TGC), low density lipoprotein (LDL) and high density lipoprotein (HDL). Results showed that Systolic, diastolic, mean arterial and pulse pressures (mmHg) were significantly (p<0.05) higher in the HSD-fed rats (HSDFR) compared to the CR. KV attenuated elevation in blood pressure and prevented dyslipidemia in HSDFR. Also, serum levels of TC, TGC, LDL were higher while HDL levels were lower in the salt-induced hypertensive rats  compared to the CR. TC, TGC, LDL, Total/HDL and LDL/HDL ratios decreased significantly (p<0.05) in HSDFR -co treated with KV compared to HSDFR. Heart rate showed no significant change. The results from the present study demonstrated that, kolaviron attenuates elevation in blood pressure and ameliorates dyslipidemia in salt-induced hypertension and may be effective in the improvement of atherogenic indices and  protection in the cardiovascular system

Kolaviron Attenuates Elevation in Blood Pressure and Ameliorates Dyslipidemia In Salt-Induced Hypertensive Sprague-Dalwey Rats