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Cross-sectional studies have shown that the dysregulation of one-carbon metabolism is associated with cognitive impairment. However, the findings of longitudinal studies investigating this association have been inconsistent. This study investigated the prospective associations between cognitive decline and the levels of folate, vitamin B(12) and homocysteine both at baseline and over course of the study period.

Folate, Vitamin B12, and Homocysteine as Risk Factors for Cognitive Decline in the Elderly