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The glass/Ta(5.8 nm)/NiFe(5 nm)/Cu(2.3 nm)/NiFe(3 nm)/IrMn(12 nm)/Ta(5.8 nm) GMR-SV (giantmagnetoresistance-spin valve) multilayer structure films with a magnetoresistance ratio (MR) of 5.0 % and a magnetic sensitivity (MS) of 1.5 %/Oe was deposited by dc magnetron sputtering method. Also, GMR-SV device having a width of 7 μm~8 μm similar to the diameter of RBC (red blood cell) was fabricated by the light lithography process. When RBCs coupled with several magnetic beads with a diameter of 1 μm dropped upon the GMR-SV device having MR = 1.06 % and MS = 0.3 %/Oe, there is observed the variation of about included of a resistance value of ΔR = 0.4 Ω and ΔMR = 0.15 % around a external magnetic field of −0.6 Oe. From these results, the GMR-SV device having the width magnitude of a few micron size can be applied as the biosensor for the analysis of a new magnetic property of hemoglobin inside of RBC combined to magnetic beads.

Detection Characteristics of a Red Blood Cell Coupled with Micron Magnetic Beads by Using GMR-SV Device