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Objective: The aim of the study is evaluating the correlation between prognostic histopathological factors in malignant melanoma and the expression of nm23 and p16 proteins and to investigate the value of these proteins as a prognostic factor.\udMaterials and Method:\udBreslow index, Clark level, presence of ulceration and lymphocytic infiltration were evaluated in HE sections of 40 malignant melanoma cases. UV light exposure of tumor locations were also recorded. Nm23 and p16 antibodies were applied on tumor sections and immunoreactivity was evaluated semi-quantitatively.\udResults:\udAccording to extent of expression, nm23 protein was correlated with lymphocytic infiltration(p=0,00) where it was inversely proportional with Breslow index(p=0,022). No statistical correlation was determined between expression of this protein and Clark level(p=0,082 and ulceration(p=0,25). According to the intensity, expression of nm23 protein was correlated with lymphocytic infiltration(p=0,00) and it was inversely proportional with Breslow index(p=0,002), Clark level(p=0,004) and ulceration(p=0,014). The expression of p16 protein was correlated with lymphocytic infiltration according to both extensivines and intensity(p=0,003p=0,012), but it was correlated with ulceration according to intensity only (p=0,014). No statistical correlation with Breslow index(p=0,129p=0,174) and Clark level(p=0,072, p=0,08) was determined with expression of p16 protein. UV light exposure and expression of both nm23(p=0,877p=0,563) and p16(p=0,47p=0,810) proteins were not statistically correlated.\udConclusion:\udIn our study although we did not find any statistical correlation between expression of p16 protein and the majority of the prognostic factors, our findings suggest slight correlation with prognosis that additional studies of larger series are needed to be done to define the expression differences. Our findings indicate prominent correlation between the expression of nm23 protein and prognostic factors. The expression of nm23 protein is thought to be an additional parameter to prognostic factors and it might explain the progress and survival that are not correlated with prognostic factors

Comparison of prognostic histopathological features in malignant melanoma with the expression of nm23 and p16 proteins