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Background: Rosuvastatin calcium, a synthetic BCS class-II drug with low solubility and high permeability utilized in hyperlipidaemia management. In the present investigation, an attempt was made towards the modification of the physicochemical properties of rosuvastatin calcium by applying crystal engineering to prepare a cocrystal form. Cocrystals of rosuvastatin calcium with GRAS status co-former L-Asparagine were prepared by utilizing solvent evaporation method. Result: The Obtained cocrystals was evaluated by Fourier transform infrared spectroscopy, powder X-ray diffraction, FT-Nuclear magnetic resonance spectroscopy, Scanning electron microscopy, and differential scanning calorimetry. Powder X-ray diffraction studies revealed the presence of unique crystalline peaks, which provides the interaction details of API and the co-former. The changes in the thermal behaviour of cocrystals were confirmed by differential scanning calorimetry studies. Alteration in the chemical shift values of FT-NMR at OH group confirms the hydrogen bond interaction between drug and co-former. Comparative studies on the solubility and dissolution rate were conducted and exhibited an almost 2-fold higher than the parent drug. Conclusion: A new co-crystal form of rosuvastatin calcium was obtained with enhanced solubility and dissolution rate than the parent drug, which encloses new circumstances for use of these cocrystals

Cocrystal Construction Between Rosuvastatin Calcium and L-asparagine with Enhanced Solubility and Dissolution Rate