Open AccessHepatoprotective Activity of Gentisic Acid on 5-Fluorouracil-induced Hepatotoxicity in Wistar Rats
Author(s) -
Rohini Pujari,
D. D. Bandawane
Publication year - 2020
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2020.95870
Subject(s) - gentisic acid , pharmacology , fluorouracil , chemistry , traditional medicine , medicine , biochemistry , cancer , salicylic acid
5-Fluorouracil (5-FU) is a very potent and effective antineoplastic drug that has been widely used for the management of various types of cancer. However, the clinical use of 5-FU is often associated with severe toxicities including hepatotoxicity, which limit its therapeutic use as a potent anticancer agent. The present study aimed to evaluate the hepatoprotective activity of a plant phenolic acid, gentisic acid (GA) (2,5-dihyroxybenzoic acid), against hepatotoxicity induced by 5-FU administration in Wistar rats.
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