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Soybeans (Glycine max (L.) are a good source of isoflavones. The main isoflavone components of soybean are daidzein, genistein and glycitein. World soybean production is very high and, because of its pharmacological activity, soy isoflavone intake over a long period of time can result in interactions with drugs. This review summarises soy isoflavonedrug interactions based on pharmacokinetic parameters. Soy isoflavones have been reported to have pharmacokinetic interactions with celecoxib, theophylline, paclitaxel, midazolam, imatinib, carbamazepine, valproic acid, repaglinide, omeprazole and danofloxacin. This is due to changes in the AUC, Cmax, tmax, Cl and t1/2 of drugs when delivered together with soy isoflavones. This mechanism of pharmacokinetic interaction occurs through the inhibition/induction of drug metabolizing enzymes such as CYP3A4, CYP2A1 and CYP2C9, or through the inhibition of drug transporters such as P-gp and BCRP. Thus, the consumption of soybean, soy isoflavones or soy products with drugs needs to be reconsidered. Keyword: Soybean, Isoflavones, Pharmacokinetic Interaction, Drug Metabolizing Enzyme, Drug Transporter Öz Soya fasulyesi (Glycine max (L.) iyi bir izoflavon kaynağıdır.Soyanın ana izoflavon bileşenleri daidzein, genistein ve glisitindir.Dünya soya fasulyesi üretimi çok yüksektir ve farmakolojik aktivitesi nedeniyle uzun süre soya izoflavon alımı zaman ilaçlarla etkileşimlere neden olabilir. Bu derleme soya izoflavon-ilaç etkileşimlerini farmakokinetik parametrelere göre özetlemektedir. Soya izoflavonlarının selekoksib, teofilin, paklitaksel, midazolam, un or cte d p roo f

Isoflavones in Soybean as a Daily Nutrient: The Mechanisms of Action and How They Alter the Pharmacokinetics of Drugs