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Desoximetasone (DMS) is a widely recommended drug for the topical treatment of plaque psoriasis. However, low water solubility and short half life of DMS present major obstacles in the development of an effective topical formulation. Thus, there is a demand for the development of a safe and effective topical system to deliver hydrophobic DMS. The present study aimed to develop an Aloe vera -based emulgel formulation to ensure enhanced skin deposition of DMS for effective treatment of plaque psoriasis.

Development of an <i>Aloe vera</i>-based Emulgel for the Topical Delivery of Desoximetasone