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In the current investigation a novel sterculia foetida and pullulan based semiinterpenetrating polymer network gastroretentive microsphere formulation was prepared by emulsion crosslinking method and optimized by central composite design. METHODS: The effect of amount of glutraldehyde, sterculia foetida and pullulan on percent drug entrapment efficiency (% EE), percent mucoadhesion at 12h and percent in vitro drug release at 12h (% Q12h) were optimized. The microspheres were also characterized by SEM, FTIR and DSC. RESULTS: The formulation containing 4%v/v Glutraldehyde, 8.28%w/v pullulan and 2.14% w/v sterculia foetida had 88.75± 1.18% EF, gave 80.43± 1.2% drug release in 12 h and 81.73± 1.50% mucoadhesion at 12 h was considered optimum and was used for in-vivo radiographic study. DISCUSSION AND CONCLUSION: From the study it was concluded that semiinterpenetrating polymer network microspheres loaded with amoxicillin trihydrate were successfully prepared using Sterculia foetida and pullulan gum. The prolong retention of microspheres in the stomach with sustained drug release could effectively act against the HPyroli reservoir in the stomach and improve the therapeutic effectiveness of amoxicillin trihydrate against H-Pyroli.

turkish journal of pharmaceutical sciences

Preparation of Sterculia foetida - pullulan based semi-interpenetrating polymer network gastroretentive microspheres of amoxicillin trihydrate and optimization by response surface methodology