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Gastrointestinal angiodysplasia (GIA) is the most common digestive tract vascular malformation, often causing recurrent gastrointestinal bleeding. Despite association with certain hereditary diseases [1,2,3], most GIAs are acquired, associated with aortic stenosis, hemodialysis, malignancies, or liver cirrhosis or idiopathic, and they appear among the elderly (>60 years) [4]. Advances in endoscopy brought about management improvements, but due to numerous lesions disseminated over the digestive tract, treatment of GIA remains a clinical challenge. Novel studies suggested that the use of thalidomide might be beneficial in these patients due to its antiangiogenic properties [5,6]. Thalidomide and its modern analogues currently represent a backbone treatment of another disease: multiple myeloma (MM) [7]. Here we would like to present a case of successful MM and GIA treatment with thalidomide.

turkish journal of hematology

Successful Treatment of Recurrent Gastrointestinal Bleeding due to Small Intestine Angiodysplasia and Multiple Myeloma with Thalidomide – Two Birds with One Stone