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Central nervous system involvement (CNSi) is rare in the course of chronic lymphocytic leukemia (CLL). The frequency ranges from 0.8% to 1% [1], and it is often underreported. Diagnosis is challenging and there is no consensus on the optimal therapy or survival. CNSi manifests as either leptomeningeal infiltration or a focal parenchymal lesion, or both [1]. We describe the case of a CLL patient who progressed with parenchymal CNS involvement and was successfully treated with ibrutinib.

Successful Treatment of Chronic Lymphocytic Leukemia Multifocal Central Nervous System Involvement with Ibrutinib