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A 14-year-old boy was diagnosed with acute lymphoblastic leukemia. Febrile neutropenia developed during induction. Imipenem and teicoplanin were started because of severe mucositis. Viral tests and bacterial cultures were unrevealing. On follow-up, a painful papular rash had appeared and oral mucositis had become worse (Figure 1). Stevens-Johnson syndrome (SJS)/ toxic epidermal necrolysis (TEN) was suspected. Intravenous immunoglobulin (IVIG) at 1 g/kg/day and methylprednisolone at 1 mg/kg/day were started. The lesions regressed in 1 week (Figure 2). Skin biopsy was consistent with SJS/TEN. Informed consent was obtained.

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Should Be Kept in Mind in Children with Febrile Neutropenia, Oral Cavity Lesions, and Skin Rash